Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats
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منابع مشابه
Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats
Effects of repeated postnatal administration of caffeine (10 and 20mg/kg s.c. daily from P7 to P11) were studied in two models of epileptic seizures characterized by spike-and-wave EEG rhythm in 18- and 25-day-old rats. Rhythmic metrazol activity (RMA, model of human absences) was induced by low dose of pentylenetetrazol (PTZ, 20mg/kg or 40mg/kg, i.p.) and minimal clonic seizures (model of huma...
متن کاملDifferent effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood.
BACKGROUND Postnatal treatment with caffeine from P7 to P11 (10 or 20 mg/kg daily) resulted in transient changes in two pentylenetetrazole (PTZ)-induced models of epileptic seizures characterized by spike-and-wave EEG rhythm in immature rats. To know if some changes persist into adulthood we studied these models in young adult Wistar rats. METHODS Caffeine treatment at a daily dose of 10 and/...
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ژورنال
عنوان ژورنال: Seizure
سال: 2009
ISSN: 1059-1311
DOI: 10.1016/j.seizure.2009.04.002